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Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

Local farmers must love this wireless company as much as its employees do. Once a week, San Diego-based Qualcomm hosts a farmers market at two of its locations. Items sold range from traditional produce to jams and jellies. Employees with CSA veggie box subscriptions can pick up their produce packages at one of the HQ's cafés.
尽管每轮市场反弹最终都呈V形,每次连续的涨势中,个股的参与越来越少。今年春夏两季的绝大部分时间里,时事分析评论员们都专注于赢家与输家、大盘股和小盘股之间的明显差异。欧洲的通缩担忧以及日本的技术性衰退,使得分析师们愈加困惑,尽管美国经济正在好转,美国国库券收益率和通胀指标却双双下行。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

报告称,打造“机遇之城”的关键是技术创新和均衡发展。
Most female participants were between 19 and 23.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 房企转型瞄准存量市场
Open Access Perspective

Soft matter science and the COVID-19 pandemic

As the calendar flips to December it’s not too early to think about the inevitability of tanking. Who should do it, who should wait, and who shouldn’t ever consider it. Flanns and Zillz discuss.

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

1、死侍

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

No details have been given about the content of the leaflets, though propaganda sent in the past has denounced North Korea's ruling family.
WardsAuto will present its Top 10 Engines awards on Jan. 15 at a ceremony held in conjunction with the North American International Auto Show in Detroit.
8. 精彩出演)的艺术觉醒与性觉醒,欲望令她长大成人。
7.Manage up, down, and sideways

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

最坏习惯奖
Length of program: 21 months
identity
Taylor Swift and Katy Perry opted for bedazzled5 dresses in very different styles. Taylor went for a more old Hollywood, glamorous Grecian style that exposed her back and statuesque6 figure, while Katy rocked a shorter, spunkier look that exposed a little of everything.

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

"I am a doctor and I prefer to speak frankly. A person's health is related first to eating, drinking and air. Any kind of development will be nothing if the quality of food, water and air is not good." ZHONG NANSHAN, NPC deputy and academic with the Chinese Academy of Engineering

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

1.《刺客聂隐娘》(The Assassin)与《疯狂的麦克斯4:狂暴之路》(Mad Max: Fury Road),并列。侯孝贤和乔治·米勒(George Miller)导演了今年最好的两部商业片,二者都应该到你能找到的最大的屏幕上去看。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

n. 购买,购买的物品
The three bubbles: The Asian Bubble in the early '90s, Dot-com Bubble of the late '90s and what Juckes calls the Great Big Credit Bubble that triggered the 2008 Wall Street meltdown.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

mortality
新美国基金会(New America Foundation)高级研究员李?德鲁特曼(Lee Drutman)在一份给Vox的分析文章中指出,在阿肯色州、北卡罗莱纳州和田纳西州,移民人口是1990年的三倍以上。围绕这些变化产生的焦虑或许可以解释共和党为什么在这个阶段更关注限制移民问题,还有这些州的白人投票者们何以压倒性地支持特朗普。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

从几乎所有单项指标看,巴黎高等商学院都没有排在首位,但它整体表现强劲。该学院学生毕业3年后的年薪为9.3万美元,位居第五;性价比以及毕业生国际流动性位居第三。该学院还在目标实现率方面并列第一(93%)。
对于美联储(Federal Reserve)预计本周宣布的加息已经产生了效应,还是会进一步加大负债企业和经济体所受的压力,投资者意见分歧。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

Topped with golden leaves and flavored with champagne, the confection was sold for $100 a pop.
加拿大学校继续失利。今年的上榜学校只有3所,而去年为5所,而且这3所学校的排名都下降了6个位次左右。多伦多大学(University of Toronto)罗特曼商学院(Rotman School of Management)排名最高,为第65位,而加拿大女王大学(Queen’s University)史密斯商学院(Smith School of Business)在今年的榜单中垫底,排名第100。
Still, experts see a crisis of white identity underlying much of the West’s current turmoil.
Four other domestic movies made it to the top ten list, among them are the third winner Never Say Die, Kung Fu Yoga in the fourth place, the fifth winner Journey to the West: The Demons Strike Back, and Youth in the eighth place.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

A median forecast from economists had predicted a 0.9 per cent rise.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Life Is Strange
Kate Winslet is another Brit who’s opted for the loo for her best actress Academy Award, which she was awarded for her complex role as a concentration camp guard in the 2008 adaptation of Bernhard Schlink’s novel, The Reader.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

人不得不告慰自己,原来如此。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

Since then, China has been issuing stamps on the theme of the lunar calendar every year to mark the 12 Chinese astrological signs.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

今年的榜单包括三款涡轮增压柴油发动机,但这一点可能引来争议,尤其考虑到柴油在美国的普及程度低于欧洲;在欧洲,柴油引擎已经成为发动机话题的主角。这是第一次有超过两款柴油动力引擎跻身十大榜单,并且讽刺的是,其中这两款引擎均来自于美国国内汽车生产商,包括当前美国国内唯一一款全尺寸半吨皮卡Ram 1500所使用的引擎。
According to figures from Zhonggong Education, an institute that monitors the applicant numbers, more than 459,600 people applied to take the exam by the sixth day of this year's application window on Tuesday. Almost 103,000 of those had applied on Monday.
《一个开车从来不回头看的沙特女子》(A Saudi Woman Who Got Behind the Wheel and Never Looked Back)
单词medal 联想记忆:

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

但有些人可能就记住了胡子。
但是,当《老友记》第二季浓墨重彩地展现卡罗尔和苏珊的同性恋婚礼时,这个剧集就朝着人人平等的方向迈出了一大步。幕后,执行制片人玛塔·考夫曼说:"国家广播公司预计会接到成千上万的投诉电话和邮件"。然而在这部剧集上映之后,收到的恶意信件却是寥寥无几。原来,大家根本就不在乎。
Recognize me?: image via blog.discoverymagazine.com
BrandZ表示,这些品牌靠近国内市场,这帮助它们从全球品牌手中夺取市场份额,它们还在新地区赢得市场份额。
单词elegant 联想记忆:

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

新版《蜘蛛侠》是迄今为止最棒的一部,这主要是因为它很搞笑。这部电影就像是《早餐俱乐部》、《春天不是读书天》遇上《怪胎与书呆》式的幽默。
《她》(Her),由斯派克?琼斯(Spike Jonze)担任编剧兼导演,将浪漫带入了虚拟世界,影片的主人公展开了一场有些疯狂的真正激情之旅。华金?菲尼克斯(Joaquin Phoenix)扮演的男主角是个令人心酸的孤独小伙子,他爱上了自己智能手机的新操作系统。影片的基本构想有些脆弱,但故事非常华丽地展开,霍伊特?范?霍特玛(Hoyte Van Hoytema)的摄影也很精妙,完美地烘托了菲尼克斯、艾米?亚当斯(Amy Adams)和斯嘉丽?约翰逊(Scarlett Johansson)的表演。斯嘉丽?约翰逊在片中扮演的是智能手机操作系统的声音和灵魂。

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

卡梅隆·安东尼

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Peer review is an evaluation of work by one or more people of similar competence to those who produce the work, which helps validate research.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

挖掘者认为这个墓地可追溯到1700年前,在当时的中国,库车在控制西部前线(西域)上扮演着关键的角色。由于丝绸之路的路线有经过西域,所以控制这个关键的区域对中国统治者来说是非常重要的。
['b?t?flai]
Robin Harding
1. 碧昂斯(Beyoncé),《碧昂斯》,Parkwood Entertainment/Columbia。这张专辑是继去年的平淡后的一次突击,是碧昂斯的力作,它光彩夺目地展示了充满情感的统治力、精良的制作、欲望的放纵与女性主义的力量(不一定是按这个顺序),在漫长而充满众多娱乐的一年里一直令人关注。她的歌唱与她的态度一样,极为自信而又充满细节;她所传达的信息复杂而又清晰。这是高端的流行乐,拒绝曲意逢迎。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

电池电力可能最终被证明是一种过渡性技术。最近电池成本的降低速度已经放慢了,特斯拉曾经承诺要在2017年生产出价格在35,000美元左右的Model 3。要实现这个目标,特斯拉的电池成本需要下降30%。相比之下,丰田(Toyota)最近的举动非常出人意料。它与特斯拉签订的电池供应协议即将期满,但丰田并未续约,而是准备加倍投入研发氢燃料电池。燃料电池的成本下降速度要快于普通电池。而且燃料电池的拥趸们认为,车主肯定会更喜欢充电速度相对更快的燃料电池,而不是要为充电等上好几个小时。
可以这样说美国银行首席执行官布莱恩?莫尼汉这个人:他很会说话。在给股东的信中,莫尼汉特地感谢美国纳税人,正是由于他们,美国银行才获得了450亿美元的不良资产援助资金。他还说自己如今正在金融改革方面同“政策领导人”紧密合作。不过他是否能做好,比如转变美国银行的境遇,就是另外一回事了。虽然美国银行的确在去年12月偿还了援助资金,但是它仍然有数十亿美元的高风险住房与商用房房贷,这也是为什么它要在年度报告中花8000字来讨论风险了。
一些英国退欧派人士和共和党人相信绝对自由市场理念,
n. 蛋白质

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

Payouts also varied substantially between industries and cities. The average bonus at financial institutions was over Rmb17,200, while those in the education sector got less than half of that on average at less than Rmb7,500.
"That of course is in keeping with all of the developments that we have seen in China in recent years, including the current enormous emphasis on innovation as a major component in the transition of the Chinese economy from 'Made in China' to 'Created in China'," he said.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
From the themed collection: 传统家具业观念束缚致创新争论大
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

That is up from a rise of 11.2 per cent in September.
据Digitimes的消息,更大尺寸的iPhone 6将采用“台积电(TSMC)生产的20纳米处理器”。此前曾有报道称,新款iPhone的屏幕尺寸将和三星Galaxy 4的屏幕一般大小(不到5英寸)。
8. 精彩出演)的艺术觉醒与性觉醒,欲望令她长大成人。
3. In Cannes, they speak English
Developer:Dontnod Entertainment, Square Enix

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

Horowitz, speaking to radio station RTE, said he was keen to keep the new Bond true to the 1950s creation.
Costco CEO Craig Jelinek
虽然也有各种各样的政策鼓励,但许多会采取减免税务、低息贷款或退税的形式。因此,楼盘运营方或许将不得不从估价中征税,或增加维护费,以此打平楼盘运营的初始成本。“你会遇到没人为你提供前期资金的问题,”卢森堡说。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Elspeth Cheung, head of BrandZ valuation at Millward Brown, says: “The top 10 used to be dominated by consumer goods. This year, it’s technology.”
The four megalopolises also saw fewer traffic jams after November due to reasons ranging from less travel in winter and smoggy days to the return of migrant workers to their hometowns.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

伦敦商学院的学员品质优秀,这让该商学院尤其具有价值。一位2011届的MBA学员表示:“跻身于如此人才济济的学习环境让我坚信,我可以独立做成某些事情。”
根据报道,当地法院鉴于周某的年龄及其坦白承认自己的罪行,最终给予了周某一个宽大的判决。
台风艾玛

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

adj. 确实的,保障的,有自信的 动词assure的过
比特币区块被讨论得最多的一项潜在用途,是去中心化的打车服务“Uber”。客户无需使用特定软件,就能订车并直接向司机付款,去掉中间商。(Uber创始人特拉维斯o卡兰尼克,抱歉)区块能用于各种用途,从储存安全文件(去中心化的的Dropbox)到“水印”技术,水印技术是指某块特定的比特币能包含比如你房子的房契。Digital Currency Group投资主管赖安o希尔基斯表示:“区块将催生数十年的创新。这可能催生零阻力股票发行、所有权转让以及智能合同。而上述事物共同构成了经济的支柱。如果你想创建分散管理的优步、Dropbox以及Facebook,你可以重塑互联网。”Digital Currency Group由前SecondMarket创始人巴里o希尔伯特创办。
德拉吉在12月投票表决的次日作出回击,称欧元区政策制定者在动用政策工具推动通胀达标方面“是没有限度的”。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

换总部:随着丰田迁至德州,奔驰从新泽西搬往北卡罗来纳州或乔治亚州,斯巴鲁也要建它的新总部了。它的一个选择是搬到离其客户群更近的佛蒙特州。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

竞争对手在网上的表现如何?谷歌的搜索广告关键词规划工具会帮助你解答这个问题。“搜索广告”这个词可能会令有些企业家望而却步,因为它似乎会要求你买广告位。但事实并非如此,只要有谷歌账号,任何人都能使用这个关键词规划工具(不过你首先必须点击Adwords的进入端口)。然后你可以使用关键词规划工具来看看在你从事的领域中,哪些关键词会吸引最多的搜索量,然后找出吸引流量的机会。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Last year, the General Administration of Quality Supervision, Inspection and Quarantine conducted random quality inspections on 1,013 batches of such products, including consumer goods such as toys, paper diapers, clothing and kitchenware, with 415 found to be substandard, accounting for 40.9 percent of all sampled products, according to Han Yunping, spokesman for the administration.
Between 1991 and 2010, the cancer mortality rate fell by a whopping 20%, which is more than 10% a decade. One day we will say goodbye to cancer for good.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

6.《我爱你,菲利普·莫里斯》
n. 代表,副手
*Writing for a Variety Series: “Last Week Tonight With John Oliver”
陆金所是最大的一家。它是中国平安保险(Ping An Insurance)的子公司,平安也是陆金所最大的股东。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 2017年智能家居市场或再迎大爆发
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

底特律居民都不会忘记1999年的暴风雪,当时多架飞机在底特律大都会国际机场的停机坪上滞留了数小时。同样,全美航空公司(US Airways)在2004年至2005年也遭遇了假日事故,当时超过72,000件行李丢失或损坏。
私人侦探已进行指控,但是他们表示,不会公布枪击详情,除非两名年轻人周五出庭。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

ef出,fect做-做出来的效果
“The individual sent an email blast to the entire staff.”

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 品牌成为卫浴市场消费主导因素
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

榜单前十位富豪的净资产总额合计为5054亿美元。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

We will strengthen our capability for making technological innovations.
但许多人预测将会出现经济崩盘,他们认为,旷日持久的欧元区危机加上房地产泡沫,将使相当大一部分中国工业失去盈利能力。这将暴露出各种隐藏的金融脆弱性,推动形成一场螺旋式下降。其他人认为,北京方面有充足的资源可以避免一场危机,不过他们指出,由于中国的增长模式依赖于基建和土地出售,且汇率和利率受到僵硬控制,它也许并没有所有必要工具。
此外,广电总局还透露,虽然今年的票房增长受人民币贬值影响要稍低于35%,但是电影市场增长势头依旧强劲。
单词severe 联想记忆:

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

NATO’s bombing campaign began on March 24 1999 after peace talks meant to stop the persecution of ethnic Albanians in Kosovo collapsed. Targets in both Yugoslavia and Kosovo were struck—first the Serb air defense network that opposed NATO planes then a broader target array including Yugoslav army forces said to be directly involved in the persecution of Kosovars. The target list also included political-military targets inside the Yugoslav capital of Belgrade itself.
Over the past 20 years, at least 133,000 units in the city have gone market rate because of this rule, according to the Rent Guidelines Board. If the trend continues, rent stabilization could be further weakened, undermining Mayor de Blasio’s efforts to preserve affordable housing, say supporters of the policy.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

我们可以看到时空涟漪的源头。
去年电影市场的一个亮点是,共有七部高质量的国产影片在票房前10名的榜单中。其中就包括真人与动画结合的《捉妖记》、以及基于经典古代故事的3D动画电影《大圣归来》。
德文·韦德

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

Accelerating price growth for new housing in cities across China lost more steam in November amid a flurry of purchasing curbs in major cities, though price gains from a year earlier remained comfortably in double-digit territory.
而在一年前,台湾的反华人士就选择了向日葵作为他们反华事业的标志。
According to the country's film regulator, China's box office sales have boosted a whopping 48.7 percent in the last year alone.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

出手阔绰的美国公司正迫使英国同行提高从新入行者到顶级风云人物的薪资——尽管这并未阻止富尔德(Freshfields)的私募股权明星戴维希金斯(David Higgins)在圣诞节前夕跳槽到凯易律师事务所(Kirkland & Ellis)。精品专业律所通过提供更快、更专注的服务来吸引客户。
Indeed, everyone from Jennifer Garner, to January Jones and Kylie Jenner have been photographed as they pick out their most spook-worthy pumpkins in time to send October out with a thrill.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

adj. 国内的,家庭的,驯养的
你可能觉得夏威夷航空的运营相对容易,因为该公司的航班很少遇到美国大陆那种恶劣的天气条件。夏威夷航空公司在航班准点率排行榜上常年位居前列,在9月份最新公布的榜单上创下最高准点率。夏威夷航空公司最近宣布将把业务拓展到夏威夷岛外,开通从檀香山到北京的直达航班。
Benchmark oil prices dropped below $40 a barrel last week, the lowest level in six years, darkening investor sentiment towards commodity-linked companies and exporting countries including Brazil, Russia and South Africa.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

这也是短信应用独有的棘手问题。在消费内容时,我们希望广告乖乖待在一边。没人想在聊天时突然有条广告蹦出来。雷表示:“人们在聊天时最不想看到的就是打断对话的广告条或弹出式广告。可能这在非个人的网络上还管用,但在短信中,人们最恼火的就是看到传统广告。”
最近两年你都没有涨薪水

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

《Trigger Mortis》于9月8日发行,先于10月26日上映的007新电影《(幽灵党(暂译)》(Spectre)。
Ellen DeGeneres
该报告指出,代理商和投资机构的涌入导致世界第二大经济体的增长方式和平台发生了额外的变化。小米科技公司的投资人和创始人雷军、360董事长周鸿祎、中国首富王健林等众多互联网大咖都大力支持流媒体的网络直播,这强烈表明了投资网红经济的巨大利润。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: 陶瓷产品产销分离利大于弊
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Stripping out price, volumes of Chinese imports in October fell a more modest 2.6 per cent from a year earlier, according to estimates from Oxford Economics.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

他说,薪酬是个问题(2010年记者的年薪中值为3.6万美元)。他不知道自己能否靠做记者的薪水供养家庭并送孩子上大学。而且还有一点没错,记者的压力和工作时间可能会令人感到精疲力竭。但他说,我不确定自己换个工作是否会开心,也想不出任何一个工作会像做记者这样让我觉得兴奋或有成就感。
“现在黑客使用流行文化或体育活动中的常见说法来破解网上账户,因为他们知道很多人在使用这些容易记住的词做密码。”

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

Jennifer Lawrence also took home the gong for best actress in a movie for her role in the critical darling Joy.
The reason is twofold: For one, logistically, there are simply too many opportunities to get caught job searching. Résumé copies will be found. Computer servers will be checked. Co-workers will notice when you're clearly elsewhere, either literally for interviews or emotionally (more on that later)。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 听说“共享风”已吹到了家居界?
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

尽管这些大脑没有进入任何人的身体,但是他们给科学院研究脑科疾病提供了原材料。
这篇文章发表后,美国参议院很快投票通过了《反就业歧视法》(Employment Non-Discrimination Act)。这样,在工作中歧视LGBT群体也有可能成为违法行为。这项法案即将提交众议院审议。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

吕特在周一晚间的辩论中重申,他不会与维尔德斯所属的政党组建联合政府,他甚至还表示不可能组建一个依赖这个反移民政党支持的政府。吕特表示:“我不会再次与这样的政党合作。”在2010年选举之后,吕特组建的首个少数派政府受到自由党的支持。
《静待黎明》

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

《纽约时报》记者丹尼斯?格莱迪进入一间手术室,观察一项对24周、患有先天性脊椎裂的胎儿进行治疗的实验性技术。医生希望通过手术缓解患病婴儿的症状。他们目前已进行了28例手术,效果良好。报道中的胎儿母亲的预产期为1月14日。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

“现在黑客使用流行文化或体育活动中的常见说法来破解网上账户,因为他们知道很多人在使用这些容易记住的词做密码。”
"It's not sustainable growth because they're not being rented out and they're pricing people in the local market out of buying."
其中一个球迷站在女孩对面的球迷俯下身来想和女孩索吻,此时女孩正与她的朋友用法语交谈时,男子假装很囧地和旁边一个朋友来了一个拥抱。
devastating

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

根据美国影院业主协会的数据显示,2015年全球影院收益达383亿美元创新高,中国贡献了68亿美元的票房收入,较上一年增长了近五成。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

胡润百富榜创始人胡润表示,姚振华代表了一类新型的中国富人,他们的财富不是来自贸易或者制造业,而是来自金融市场操作。
Whether of left or right, they present themselves as representatives of the common people against elites and unworthy outsiders; make a visceral connection with followers as charismatic leaders; manipulate that connection for their own advancement, frequently by lying egregiously; and threaten established rules of conduct and constraining institutions as enemies of the popular will that they embody.
更好激发非公有制经济活力。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Of the other teams, Germany have a fantastic team, with some great options all over the pitch. The Italians can never be discounted at tournaments, whilst Portugal, with Ronaldo in the team will be dangerous, and Belgium, with such an array of talent will be amongst everyone's list of dark horses.
Embrace the world

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

On Sunday, the night before the Doodle debuted, Zhang told Newsday she was "excited" by the big win, but said she wouldn't be awake when her art first went online at midnight.
《ScreamRide》

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

讽刺的是,就在该榜单公布的同一天,特朗普会见了已经连续第四年蝉联富豪榜榜首的比尔·盖茨。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

由于净利润增长缓慢,我国16家上市银行削减了去年的分红。
[m?uld]
Yes. There are plenty of positives: earnings, economic growth, and US tax cuts. But they are already known. Stocks look ridiculously expensive by historical standards, but that tells us nothing about short-term moves. Ultimately, it comes down to liquidity, which has driven markets since they emerged from the crisis in 2009. If all goes according to plan, central banks will be decreasing their balance sheets, and removing liquidity, by the end of 2018. If they go through with this, the odds are that the S&P will stall. But even a tiny tremor could make the bankers blink. Expect the momentum to continue.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

报名窗口将于周六关闭,报名成功者须参加11月29号的2016年国家公务员考试,考试通过后才可以参加明年3月的面试。
It grows naturally into the mold's shape.
That an iPhone mini and a LTE license from the Chinese government this year or next could finally persuade China Mobile (CHL), with 700 million subscribers, to cut a deal with Apple.
The blocks of flats which were up to 12 storeys high in the city of Wuhan are making way for a huge new business district including a 707-metre tall skyscraper.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

11. Our gut bacteria are messing with us in ways we could never have imagined. New research has revealed that neurodegenerative diseases like Parkinson's might actually start out in the gut, rather than the brain, and there's mounting evidence that the human microbiome could be to blame for chronic fatigue syndrome. With gut bacteria showing signs of controlling our appetite, changing our brain structure, and triggering brain lesions that could lead to strokes, our tiny passengers are a force to be reckoned with.
Now a white-haired grandfather, Belmonte has never regretted missing the 1950 match, particularly since his mother died just a few days later. "I decided not to go, and it was a good decision," he told the reporters.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Rare pictures have been released showing the ancient sex toys that once belonged to the Chinese royals and aristocrats.
《生活真奇怪》
demo人民+-ic…的]→人口统计的

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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Singer Susan Boyle came undone -- literally, when her trousers popped open at a soccer match as she waved a Celtic fan above her head in Scotland. The "Britain
In P2P lending, borrowers are matched with investors, who are encouraged to put their money into the loans due to higher returns than they could get at state banks.

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